Category: Healthcare and medical blogs

Inducing Physical Therapy can overcome the use of Opioids!

by JSBConference -

Injuries come unnoticed, with an onset of pain it gets accustomed to the self. Often rehabilitation helps in most of the cases where medicines do not act after a certain time. Rehabilitation programs implement a similar platform to induce healing and rehab procedures.

The concern on Opioids.

There is a worldwide national concern about the use of opioids in a large scale. The Center for Disease Control and Prevention always have alternatives for reducing the overuse, but the use of medication is always the first option among patients. The study, therefore, emphasizes the fact that physical therapy can be a lot more useful, with reducing the pharmacological approach. The musculoskeletal pain arriving from various disorders have been said to get relieved from the constant use of physical therapies.

On an analysis made from the private health, insurances have insurance claims for care and prescriptions in between 2007 and 2015. The claims do promote the use of extensive medicines mostly as a direct method to lessen pain.

The study has been published lately in the Jama Network Open, with the lead author being a Professor of orthopedic surgery, Steven George. He is recognized as a well-known senior author and an orthopedic surgeon.

What did the research say?

The research has a claim which did review several outpatients and emergency room visits for the diagnosis of shoulder, neck and low back pains.

They had screened the patients who had recently taken the opioids, with further including those who didn’t file for a prescription of an opioid within a year. Furthermore, it also screened patients who had less pain including those who had visited their doctors in a span of 20 days of their initial diagnosis. These people were given at least one opioid prescription within 3 months. Accordingly, the final sample had consisted of around 88,900 patients.

How did it help?

Findings did help clinicians who were in search of pain management options and found that inducing therapies did result in fewer health risks than using the opioids.

Additionally, exercise therapy, which is altogether a component of physical therapy did reduce pain and improved functions of musculoskeletal conditions. Further studies have revealed that the patients who are at constant prescriptions of opioid treatments are always at increased risk for an overdose of the medicine and misuse.

Findings stated that adjusting with some puzzling factors, the patients who had undergone early physical therapy were using less opioid medication for knee pain. The percentage was reduced at 10.3 for the knee, 9.7 for shoulder pains and 5.1 is for back pain. The period ranges for three months to a year after the diagnosis happened. Although neck pain wasn’t something that reduced with the use of therapies.

TiO2 nanoparticle interpose microwave therapy to kill cancer cells

by JSBConference -

Nanoparticles activated by light and ultrasound has been in the studies for cancer treatments for quite a long time. However, its incorporation for the microwave was of little evidence. Researchers have shown that TiO2 nanoparticle if activated with the help of microwaves, it helps cancer cell destruction which possibly explores the opportunity for people struggling with cancer-life. 

Recent research of Nanomedicine, Nanotechnology, Biology, and Medicine an international research team put forward a proposal for the use of microwaves and nanoparticles for more effective cancer treatment. With this, the combination of two generates the production of reactive oxygen species which eventually turns out to be safer for cancer treatment with higher chances of success. 

In the radical therapy induced by microwave, the team has explained the MDT- Microdynamic Treatment as follow- It exploits the higher concentration of ROS in tumor cells. This is done to particularly drive the cancer cell-death while also maintaining normal cells harmless. 

Experiments led by the research team were in vitro and in vivo which manifested that the development of osteosarcomas can be subdued under microwave irradiation. The research papers were put forward in an international conference on nanobiotechnology. The upcoming 2nd EuroSciCon Conference on Nanotech & Nanobiotechnology 2019 explores and demonstrates such issues in the field of nanotech. 

In the long-established microwave therapy, the cells of the cancer are heated to stimulate the death of cancer. However, it becomes tough to target each cancel cell separately without disturbing the healthy or normal cells. 

As the TiO2 nanoparticles are added to produce ROS, the research team was able to reduce the heating impact of microwaves. This grew the oxidative impact to end cancer cells without affecting the normal tissues. 

Intracellular ROS are able to harm plasma membranes, DNA and mitochondria leading to the death of cancer cells. TiO2 enters cells and cause the production of ROS to destruct the mitochondria of cancer tissue. This eventually leads to apoptosis. 

If compared with cancer cells, healthy tissues have a lower and steady saturation of ROS. Hence, the research team can propose extended levels of ROS to cause the death of cancer cells without even making normal cells vulnerable. 

Though TiO2 or low-power microwave irradiation does not efficiently kill cancer cells, its combination proves success in establishing a toxic effect. To gain better results for bone cancer treatment, more than MDT, microwave ablation therapy has previously been shown to be a worthwhile treatment.

That being said, Microwave ablation therapy has applications for fighting with cancer types. Unlike the pilot case where only osteosarcomas are used. 

For activating ROS, using light such as found in photodynamic therapy could be a difficult thing for the treatment of the tumor. Especially in the occurrences where the tumor is deeply located in within the body. 

That being said, Microwaves lend the ability to penetrate deeper propagating through every type of tissue as well as nonmetallic materials. 

The results of this pilot research indicate Microdynamic Therapy is a propitious viewpoint for the treatment of cancer despite the method being only at the start and restraints are yet in the exploring phase.