Nanobiotechnology, on a curative convention!

 

Nanotechnology, on a curative convention!

Spinal cord injury has been a major disorder among all age groups. The world health organization puts forward data of around half a million people being affected with the injury in a span of 12 months. The reasons are varied with often road accidents and crashes is a major influencer.

The impact of Spinal Cord injury often manipulates with rates such as low school enrollments and participation in economic deals.

Nanotechnology for spinal cord injury offers a wide definition of scientific analysis on the treatment of adverse spinal cord injuries.

Nanobiotechnology, a complex term?

The term originates and functions as applications of small things, and the method is used to put them for the betterment in global scientific processes. Mostly abundant in the field of Biology, they are mostly referred to as Nanobiotechnological pieces of equipment.

Nanoscience and nanotechnology are the study and application of tiny things and can be used across all the other science fields, such as chemistry, biology, physics, materials science, and engineering.

The starting point!

The concept and idea behind this started with Physicist Richard Feynman who introduced the idea at a talk show meeting. The meet was held at the California Institute of Technology and made an impact of the process thereafter.

Further, he described the process being able to manipulate, and even take in control some of atoms and molecules. Moreover, the development went ahead and through proper scanning of microscopes, researchers were able to differentiate and modify individual atoms, and coined the term of nanotechnology.

Spinal Injuries and Nanobiotechnology

In the recent process of biological improvement, certain efforts are being made to induce the technology in reviving the organs as such. Heart, liver, kidneys and so on can be tackled along with complete surgery. These organs have regenerative tissues, which with the help of biological methods can progress much faster.

The process of ENVISION farther targets the paralyzed parts of the spinal cords. This can help on the rehabilitation of Parkinson and even Alzheimer’s, as per recent researches. With an introduction of the nanotechnology, specialists claim that adverse symptoms of neurological problems can be completely cured.

Current method standards are large in awakening the brain-machine interfaces. There are various cables which can link the brain activities of the patient to that of a computer. This can help in linking the patient and a computer, limiting many motor related functions. The additional processes include that of brain mapping activity, which requires large machinery working well in low-temperature operation conditions.

The future of Nanotechnology involves the coated electrodes which can perform neural interface being coupled with sensors. These can be used in conjunction with nanomaterials. One such example is that of carbon nanotubes, which acts as a supportive framework in the function of nerve cells, further enabling them to pass over the injury-prone area of the spinal cord. This further engraves an active bypass. With the advent of technology, nanotubes can act as neuronal prosthetics, promoting the process of neuroplasticity. Every such process can lead to the neurological activity of the damaged spinal cord.

Heart’s issue with the spinal cord!

As astonishing as it may sound too, the spinal cord injury does affect the heart. Current research points out that it is possible that both can be correlated.

How does this happen?

The heart goes on to change a lot just after a spinal cord injury and is dependent on how severe the injury is. Besides, after an injury has taken place, there is limited sparing of nerve fibers, this, in turn, is also minimal for the heart to function a profound level.

The research conducted does have a clinical significance to portray. The primary motive of the spinal cord injury management is to further reduce the damage which can happen during the initial days. The worsening of the injury is carried forward and can result in severe nerve damage fibers. The findings of the reports suggest that if there is a preserve of nerve fibers followed by an injury, there can be an improvement in the heart functions.This process is therefore much important in preventing any issues of heart with people who are diagnosed with spinal cord injuries.

International Conference on Nanomedicine and Nanobiotechnology in Health Care

The conference named Nanomedicinemeet 2018 focuses on the aspects of Nanotechnology in the medical department. The conference centers solely on various updated news in fields such as Nanotechnology and Engineering, Medical Nanotechnology, Tissue Engineering and so on.

It is an exclusive platform preoccupied with the various industry speakers and researchers, who interact with a broader audience. The topics covered are to showcase new researches of Nanotechnology, Material science, and various other topics.

Inducing Physical Therapy can overcome the use of Opioids!

Injuries come unnoticed, with an onset of pain it gets accustomed to the self. Often rehabilitation helps in most of the cases where medicines do not act after a certain time. Rehabilitation programs implement a similar platform to induce healing and rehab procedures.

The concern on Opioids.

There is a worldwide national concern about the use of opioids in a large scale. The Center for Disease Control and Prevention always have alternatives for reducing the overuse, but the use of medication is always the first option among patients. The study, therefore, emphasizes the fact that physical therapy can be a lot more useful, with reducing the pharmacological approach. The musculoskeletal pain arriving from various disorders have been said to get relieved from the constant use of physical therapies.

On an analysis made from the private health, insurances have insurance claims for care and prescriptions in between 2007 and 2015. The claims do promote the use of extensive medicines mostly as a direct method to lessen pain.

The study has been published lately in the Jama Network Open, with the lead author being a Professor of orthopedic surgery, Steven George. He is recognized as a well-known senior author and an orthopedic surgeon.

What did the research say?

The research has a claim which did review several outpatients and emergency room visits for the diagnosis of shoulder, neck and low back pains.

They had screened the patients who had recently taken the opioids, with further including those who didn’t file for a prescription of an opioid within a year. Furthermore, it also screened patients who had less pain including those who had visited their doctors in a span of 20 days of their initial diagnosis. These people were given at least one opioid prescription within 3 months. Accordingly, the final sample had consisted of around 88,900 patients.

How did it help?

Findings did help clinicians who were in search of pain management options and found that inducing therapies did result in fewer health risks than using the opioids.

Additionally, exercise therapy, which is altogether a component of physical therapy did reduce pain and improved functions of musculoskeletal conditions. Further studies have revealed that the patients who are at constant prescriptions of opioid treatments are always at increased risk for an overdose of the medicine and misuse.

Findings stated that adjusting with some puzzling factors, the patients who had undergone early physical therapy were using less opioid medication for knee pain. The percentage was reduced at 10.3 for the knee, 9.7 for shoulder pains and 5.1 is for back pain. The period ranges for three months to a year after the diagnosis happened. Although neck pain wasn’t something that reduced with the use of therapies.

 

Two Rays of Hopes for Seizures

Identifying the exact spot in the brain is the new development in the seizures research. This can be marked as a potential transformation in the world of epilepsy.

In regions where the income is low or middle, around 75% of people with epilepsy may not receive the treatment they need. While the disorder had become a common phenomenon, new research and development have brought two new ways to treat silent seizures in children.

The background:

In Dravet syndrome, epilepsy can start forming around the age of as early as 3 months. The infant encounters convulsive seizures wherein their arms and legs jerk repeatedly. The issue gets bigger as the infant become toddlers. However, a recent study draws these silent seizures in a mouse model of Dravet syndrome. The study further pinpoints the brain area that could be targeted to stop them.

They begin having another type of seizure which may not cause obvious convulsions but disturb responsiveness slightly making the child unconscious. This can occur more than 50 times every day. As the new research unveils new ways, the difficult challenge to detect and treat may soon end up the trouble.

That said, the research is still going on eliminating the non-convulsive seizures. As the case study taken place on mice has shown considerable transformations, it is projected to have almost a similar impact on the human Dravet Syndrome. If things fall into places, the discovery can astoundingly improve the quality of life in children who are the victim of epilepsy disorders.

This discovery encouraged two new strategies for the prevention of non-convulsive seizures simulating Dravet syndrome. There are Neurological journals being conducted for psychiatrists, scientists, brain surgeons from Europe, Dubai, Canada, US and many other parts of the world.

Getting down to the wire for the issue:

Researchers at the Epilepsy conference have already shown how neurons are highly responsible for the sending signals and eventually creating a complex network. This makes the basic and higher brain functions operational. When neurons light up, they transfer the instructed objectives for the receiving cell. This is further forwarded to the next cell to take action. Meanwhile, the inhibitory cells hinder the path of instructions, as a result, the instructions are not received at the other end. Since inhibitory cells work unduly weak, this results in excitement level getting raised at the same time.

Dating back to the previous studies in a few years ago, the research has begun emphasizing more on the cerebral cortex area of the brain, putting efforts to make it active. That being said, some of the studies are also focusing on cognition, sleep, consciousness, and attention.

If the non-convulsive seizures in children happen to get eliminated successfully, there can be better conditions which will help the victim not improve the quality of life but reach their full potential.

Among the Dravet Syndrome, more than 70% of patients have a genetic mutation which develops delays in maturing and seizures. This may seem a serious issue but it can brutally fatal, at times leading to sudden deaths. An upcoming conference addressing the issue will discuss epilepsy and will bring more light on its treatment research and much more.

The mouse model:

The conducted research showed that thalamus was the area where inhibitory cells were more active in the models of Dravet Syndrome. Research recorded brain waves detecting the abnormalities in brain activity in the mouse. It was observed that the non-convulsive seizures were more recurrent than convulsive seizures which equivalent to the ones in human patients. See how closely they matched we were encouraged that our work could translate to real people, so we went on to look for ways to stop the seizures.

Two Strategies to Reduce Seizures

When the victim experiences an absence seizure, the person appears to be absent-minded. You must have noticed how children going blank while you speak to them. This can be detrimental effects in daily life which are often misunderstood as the child not paying attention to what you are speaking.

In such cases, the person does not understand everything of what is being spoken but knows the gist of it. The instances may not be convulsive always. However, it is more difficult to treat non-convulsive seizures in patients compared to their other types.

Two ways to stop non-convulsive seizures in mice:

After manipulating the activities of particular neurons in the mouse, the neurons are controlled with laser light. brain using optogenetics, an approach that makes it possible to control the activity of neurons with laser light. They developed methods to detect seizures, and upon detection, quickly changed the activity of neurons in the thalamus to stop the seizures.

The new approach in the mouse case study allowed the researchers to pinpoint the specific cells. The research aimed at eradicating the non-convulsive seizures in Dravet Syndrome model. There was difficulty in defining

There already exists an FDA approved a drug which aims the brain activity to cause non-convulsive seizures. The only lacking part was that the drug was never used to treat epilepsy complications in children. Speaking of side effects, there was no side effect on the user post consumption of the FDA approved medication.

Since the medication has already been approved by the Food and Drug Administration, USA, it has become easier to bring it in the market as a solution for epilepsy solution.